Job Posting: Scientist/Snr Scientist in various areas at C4 Therapeutics

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Here is the mission of C4 Therapeutics:

C4 Therapeutics is developing a new class of targeted protein degradation (TPD) therapeutics for the treatment of a broad range of diseases. Our Degronimid™ platform incorporates highly selective small molecule binders to target disease-causing proteins and facilitate their rapid destruction and clearance from the cell through the natural ubiquitin/proteasome system (UPS). Because of this distinctive mechanism, Degronimids are capable of hitting many more targets, including those previously thought to be undruggable, while reducing the potential for drug resistance. The broad applicability of Degronimids, and our chemical biology platform designed for accelerated validation, have the potential to make an unprecedented impact across many diseases through multiple industry collaborations as well as proprietary programs.

Scientist/Senior Scientist in Medicine Chemistry

Responsibilities:

  • Develop and execute synthetic routes of target molecules, including work up, purification, isolation, and characterization of products.  Develop scalable routes of preclinical drug-candidates.
  • Optimize drug candidates through interpretation of complex data sets through iterative SAR.
  • Utilize computational approaches, including structure guided drug design, to optimize chemical leads.
  • Work with a multidisciplinary groups to initiate and advance drug discovery programs.
  • Manage external study execution at contract research organizations and engage with extramural industry and academic collaborators.
  • Contribute to the writing of patents, scientific presentations, and publications
  • Critically analyze data and communicate findings effectively to multidisciplinary team members and senior management.

Qualifications:

  • Ph.D. in organic or medicinal chemistry.
  • Minimum of 5 years of relevant experience, preferably in the biopharma/pharma setting.
  • Proven scientific track record of advancing small molecules through stage gate milestones from HID through candidate selection.
  • Expertise in synthetic organic chemistry, including methodologies, transformations, and mechanisms.
  • Demonstrated expertise in multi-step synthesis and strong knowledge of techniques related to purification and characterization of organic compounds (NMR, MS, HPLC, etc.).
  • Ability to interpret complex datasets to optimize chemical leads through SAR.
  • Ability to work independently and apply experience and knowledge to solve difficult synthetic challenges and provide useful guidance to other chemists on the project team.
  • Strong motivation, independence, and ability to work in a high-pace multidisciplinary, matrix environment with minimal supervision.
  • Demonstrated ability to effectively manage and mentor research staff.
  • Excellent interpersonal as well as oral and written communication skills required.

Interested candidates: Please send your resume, CV and any supplemental materials to careers@c4therapeutics.com

Scientist/Senior Scientist in In Vitro Pharmacology

Responsibilities:

  • Develop, validate, implement and execute biochemical and biophysical assays for medium and high throughput screening to support target identification and lead optimization for small molecule drug discovery.
  • Implement novel in vitro screening strategies and design screening and counter screening funnels to evaluate affinity, potency, and mechanism of action of drug candidates.
  • Monitor assay quality and troubleshoot issues with assay performance.
  • Work with a multidisciplinary groups (Biology, Medicinal Chemistry, and Pharmacology) to initiate and advance drug discovery programs.
  • Critically analyze data and communicate findings effectively to multidisciplinary team members and senior management.

Qualifications:

  • Ph.D. in Biochemistry, Pharmacology or a related field.
  • Minimum of 5 years of relevant experience, preferably in the biopharma/pharma setting.
  • Proven scientific track record in the development and execution of both biochemical and cell based assays to support drug discovery.
  • Demonstrated knowledge of biochemical and biophysical assay formats and readouts.
  • Strong motivation, independence, and ability to work in a high-pace multidisciplinary, matrix environment with minimal supervision.
  • Strong problem solving skills.
  • Demonstrated ability to effectively manage and mentor research staff.
  • Excellent interpersonal as well as oral and written communication skills required.

Interested candidates: Please send your resume, CV and any supplemental materials to careers@c4therapeutics.com

Scientist/Senior Scientist in Drug Discovery

Responsibilities:

  • Independently design and execute experiments to advance small molecule drug discovery programs.
  • Identify and implement target- and cell-based assays to identify/validate compound mechanism of action, inform on target and pathway modulation, and inform on cellular response to target inhibition.
  • Work with a multidisciplinary groups (Medicinal Chemistry, Biochemistry, and Pharmacology) to initiate and advance drug discovery programs.
  • Manage external study execution at contract research organizations and engage with extramural industry and academic collaborators.
  • Critically analyze data and communicate findings effectively to multidisciplinary team members and senior management.

Qualifications:

  • Ph.D. in Biology or a related field.
  • Minimum of 5 years of relevant experience, preferably in the biopharma/pharma setting.
  • Knowledge of drug discovery from target identification through clinical candidate selection.
  • In depth knowledge of oncology targets and molecular pathways and the ability to translate this knowledge into drug discovery and development endpoints.
  • Strong motivation, independence, and ability to work in a high-pace multidisciplinary, matrix environment with minimal supervision.
  • Experience working with academic collaborators and contract research organizations is preferred.
  • Strong problem solving skills.
  • Demonstrated ability to effectively manage and mentor research staff.
  • Excellent interpersonal as well as oral and written communication skills required.

Interested candidates: Please send your resume, CV and any supplemental materials to careers@c4therapeutics.com

 

 

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